Targeting protein localization for anti-infective therapy
نویسندگان
چکیده
منابع مشابه
Oligopeptide Targeting Sortase A as Potential Anti-infective Therapy for Staphylococcus aureus
Sortase A (SrtA)-catalyzed anchorage of surface proteins in most Gram-positive bacteria is indispensable for their virulence, suggesting that this transpeptidase is a promising target for antivirulence therapy. Here, an oligopeptide, LPRDA, was identified as an effective inhibitor of SrtA via virtual screening based on the LPXTG substrate sequence, and it was found to inhibit SrtA activity in v...
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ژورنال
عنوان ژورنال: Virulence
سال: 2017
ISSN: 2150-5594,2150-5608
DOI: 10.1080/21505594.2017.1342921